Section: Partnerships and Cooperations

European Initiatives

Collaborations in European Programs, except FP7

• Program: FP6 - LSH

• Project acronym: MOSAR

• Project title: Mastering hOSpital Antimicrobial Resistance and its spread into the community

• Duration: 2008 – 2012

• Coordinator: INSERM

• Other partners: University of Antwerp (Belgium), National Medicines Institute (Poland), August Pi i Sunyer biomedical research Institute (Spain), University Medical Center Utrecht (Netherlands), University of Geneva Hospitals (Swisslands), Tel Aviv Medical Center (Israel), Health Protection Agency (UK), Medical school of Paris 12 University (France), Pasteur Institute (France), Inserm-Transfert (France), Ingen Biosciences (France), BiologischeAnalysensystemGmbH (Germany), AmpTec GmbH (Germany), Array-On GmbH (Germany)

• Abstract: MOSAR is an Integrated Project supported for 5 years by the European Commission under the Life Science Health Priority of the Sixth Framework Program. Infections caused by antimicrobial-resistant bacteria (AMRB) account for an increasing proportion of healthcare-associated infections, particularly in high-risk units such as intensive care units and surgery; patients discharged to rehabilitation units often remain carriers of AMRB, contributing to their dissemination into longer-term care areas and within the community. The overall objective of MOSAR is to gain breakthrough knowledge in the dynamics of transmission of AMRB, and address highly controversial issues by testing strategies to combat the emergence and spread of antimicrobial resistance, focusing on the major and emerging multi-drug antimicrobial resistant microorganisms in hospitals, now spreading into the community. Microbial genomics and human response to carriage of AMRB will be integrated with health sciences research, including interventional controlled studies in diverse hospital settings, mathematical modeling of resistance dynamics, and health economics. Results from MOSAR will inform healthcare workers and decision-makers on strategies for anticipating and mastering antimicrobial resistance.